Sentence examples for bone microenvironment in both from inspiring English sources
These observations suggest a role for the differential rigidity of the mineralized bone microenvironment in both the initiation and maintenance of the vicious cycle when osteolytic tumor cells metastasize to bone.
These observations suggest a role for the differential rigidity of the mineralized bone microenvironment in early stages of tumor-induced osteolysis, which is especially important in metastatic cancer since many cancers (such as those of the breast and lung) preferentially metastasize to bone.
Collectively, these data demonstrate that the osteolytic bone microenvironment in our mouse model mimics the bone microenvironment in human breast cancer but not that of other metastatic microenvironments (i.e., lung and brain metastases).
Taken together, these results strongly showed that functional FGFR1 signalling occurs in the human bone microenvironment in ESFTs.
It is difficult to know or to evaluate the concentrations of bisphosphonates that are reached in the bone microenvironment in vivo.
To assess the therapy-specific effects on the bone microenvironment in patients with metastatic castrate-resistant disease, patients who received bisphosphonates (n=17) were excluded from the subsequent analyses.
Another possibility is that the bone microenvironment in estrogen-exposed women better supports the survival and expansion of disseminated tumor cells in the endosteal niche.
The importance of the bone microenvironment in determining tumor cell colonization and growth is also broadly accepted, commonly named the "seed and soil" theory [ 4- 6].
Although both metastatic BC cell lines disseminated more frequently to hTEBCs compared to mice hind limbs, the metastatic process was not specific to the humanized bone microenvironment in our model.
In this study, we identified and used a TB microenvironment-specific gene expression signature from this model to extend our understanding of the metastatic bone microenvironment in human disease and to predict potential therapeutic targets.
The concept of the vicious cycle of bone metastases emphasizes the cross-talk between tumor cells and the bone microenvironment in the process of tumor growth and bone destruction [ 36, 37].
