Sentence examples for bone microenvironment in from inspiring English sources
These observations suggest a role for the differential rigidity of the mineralized bone microenvironment in both the initiation and maintenance of the vicious cycle when osteolytic tumor cells metastasize to bone.
These observations suggest a role for the differential rigidity of the mineralized bone microenvironment in early stages of tumor-induced osteolysis, which is especially important in metastatic cancer since many cancers (such as those of the breast and lung) preferentially metastasize to bone.
Collectively, these data demonstrate that the osteolytic bone microenvironment in our mouse model mimics the bone microenvironment in human breast cancer but not that of other metastatic microenvironments (i.e., lung and brain metastases).
Taken together, these results strongly showed that functional FGFR1 signalling occurs in the human bone microenvironment in ESFTs.
It is difficult to know or to evaluate the concentrations of bisphosphonates that are reached in the bone microenvironment in vivo.
The importance of the bone microenvironment in determining tumor cell colonization and growth is also broadly accepted, commonly named the "seed and soil" theory [ 4- 6].
Hence, the crosstalk between breast cancer cells and the bone microenvironment results in a vicious cycle of bone destruction and increased tumor growth in bone.
Zhang M, et al. Bone microenvironment changes in latexin expression promote chemoresistance.
This reciprocal interaction between breast-cancer cells and the bone microenvironment results in a vicious cycle that increases both bone destruction and increases tumor burden and metastasis [ 19].
The importance of interactions between tumor cells and other cells in the bone microenvironment was demonstrated in the 1990s by the work of Dr. Greg Mundy and others in the field.
