Sentence examples for bone metastasis using the from inspiring English sources
In the present study, we combined doxycycline together with zoledronic acid as a possible modality to prevent or reduce the tumour burden from bone metastasis using the experimental breast cancer MDA-MB-231 mouse model.
The aim of this work was to establish a 3D cell culture model of prostate cancer bone metastasis using collagen-based scaffolds, to characterise this model, and to assess the potential of the model to evaluate delivery of gene therapeutics designed to target bone metastases.
Previous studies with humanized xenograft models of BC bone metastasis using human bone chips reported a species-specificity of cancer osteotropism (Kuperwasser et al., 2005; Yang et al., 2007; Lam et al., 2009b).
In this study, to clarify the role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in osteolysis because of bone metastasis, we examined the expression of RANKL and MMPs in bone with metastasis using the intracardiac injection of breast cancer cells.
Although other drugs against bone metastasis have used the same strategy of inhibiting osteoclasts or bone turnover, none have been as successful in clinical trials as bisphosphonates and denosumab.
Bone metastasis experiments using 4T1 cells and transfectants were performed using female BALB/cByJ mice of 6 weeks of age.
Current bone metastasis treatments using powerful anti-resorbtive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progression.
Bone metastasis experiments using MDA-B02 cells and transfectants were performed in female BALB/C nude mice of 4 weeks of age as previously described [4].
In the present study, we investigated the effects of blocking ALDH7A1 activity on prostate cancer growth and (bone) metastasis by using lentiviral short hairpin RNA interference.
This suggests that our osteolytic model may be adapted to study human breast cancer bone metastasis directly using any of these 16 human cell lines.
Research into a new method of detecting skeletal metastasis using bone metabolic markers is underway [ 20].
