It could be shown that Sr was incorporated mainly in mineralized bone matrix, which was formed during Sr ranelate treatment.
Src signalling is instrumental in formation of the sealing zone between the osteoclast and bone matrix, which is necessary for bone resorption (Destaing et al, 2008).
Tiludronate, by inhibiting the ATP-dependent proton pumps located in the plasma membranes of the osteoclasts [ 43], can reduce the acidification of the bone matrix, which is the first step in the bone resorption process.
For example, implants of lathyritic matrix, which are defective in cross-links in the structure of the bone collagen, produce neither cartilage nor bone.
During the process of cell differentiation, osteoblasts produce the bone extracellular matrix, which is composed of collagenous and non-collagenous proteins.
Bone tissue is a complex biomaterial composed of a solid mineral matrix, which is filled by bone marrow (a soft interstitial material).
Bone consists of a calcified organic matrix, which is composed of 90% type I collagen [ 42].
Dentin matrix, which is highly permeable to demineralizing solutions and more highly cross-linked than bone matrix, produces a high yield of new bone even in dogs.
Moreover, KS483 cell model is among few osteoblastic culture systems that can produce discrete, three-dimensionally organized mineralized matrices which are recognizably bone like.
Hydroxyapatite is also a well-documented component of bone, and the deposition of it in bone tissue requires the coordinated expression of several bone matrix proteins, which are synthesised by cells of osteoblastic lineage [ 4].
