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At 4 weeks, cells with Y-chromosomes were distributed in the new bone matrix throughout the BCP granule implant.
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Osteocytes, former osteoblasts buried within the bone matrix during the process of bone deposition, are distributed throughout bone in numbers that far exceed either osteoclasts or osteoblasts [2], [3].
Cathepsin K and MMPs catalyze the degradation of bone matrix, dissolution of the bone mineral, and resorption of the bone.
Zone of ossification: Osteoblasts deposit bone matrix on the exposed plates of calcified cartilage.
The term mineralized bone matrix will describe both the osteons and the interstitial bone in the osteonal bone region and bone packets in cancellous bone region.
BSP is a major structural protein of the bone matrix, and OCN is the most abundant noncollagenous bone matrix protein.
Osteoblasts also promote bone matrix mineralization, thus closing the virtuous circle of bone remodeling.
Medical reference books say a fracture needs two to three months before it is strengthened by new bone matrix and six months before the patient regains full power.
They follow the osteoclasts, reforming the bone matrix.
An important function of bone remodelling is the repair of microcracks accumulating in the bone matrix due to mechanical loading.
In women, this accelerates after menopause because the loss of estrogen translates into less collagen for the bone matrix.
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CEO of Professional Science Editing for Scientists @ prosciediting.com