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Bone mass is a changeable parameter.
In particular, low bone mass is a major determinant of the risk of fracture once a fall begins.
Adult bone mass is a function of both bone size and density [23]; both these variables influence fracture risk [24,25].
Reduced bone mass is a result of an imbalance between the tightly regulated processes of bone formation and bone resorption, controlled by osteoblasts and osteoclasts respectively.
Low bone mass is a clinical characteristic of OI, and individuals with this disorder tend to have markedly reduced areal bone mineral density (BMD).
Although reduced bone mass is a hallmark of the disease, microarchitectural deterioration of bone and increased bone fragility are also present.
Similar(49)
Osteoporosis, the loss of bone mass, is an important concern as we age.
However, since peak bone mass is an important predictor for life-time risk of osteoporosis the observed differences at young adult age may be more important than possible changes observed earlier.
Bone mass is an important determinant of strength and accounts for the majority of the bone's resistance to fracture.
Peak bone mass is an important clinical phenotype as it has been shown to associate with fracture risk in later life (20).
Low bone mass is an important component of the risk of fracture as well as non-skeletal factors such as the propensity to fall.
More suggestions(19)
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