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It was also found that the three-dimensional configuration of BMP-induced bone mass could be controlled.
Since some polymorphic variations of the AR confer increased androgen sensitivity [8], [9], differences in the strength of the association between circulating testosterone and bone mass could be explained by differences in the polymorphic variation of the ARs [7].
This suggests that bone mass could be influenced by SHBG through the regulation of free testosterone levels.
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These results, together with the biomarker data, suggest that the enhanced loss of bone mass could in part be due to an increase in bone resorption.
Our hypotheses concerning the association between the general outcome of AN during childhood and adolescence and bone mass accrual could be confirmed.
Women at age 55 60 reach a mean T-score of −1.0 which could indicate that many of these women may have low bone mass and could be at risk of having osteopenia [ 22].
Although galectin-8 can potentially bind to receptors that both negatively (LRP1) and positively (MRC2 and uPAR) regulate RANKL expression, the net effect is still an increase in RANKL expression and reduction in bone mass, which could be attributed, for example, to different expression levels of these receptors in osteoblasts.
Although these determinants, together with bone mass, could potentially describe or even predict the mechanical competence of bone, the connections between these factors are still unknown, as is the effect of each factor on the final outcome.
However, the influence of this gut-bone axis on bone mass could not explain the increase in bone mass observed in another study with SSRI's [ 14].
Although at this time their small sample and range preclude any meaningful statistical comparisons between the limb scaling patterns of lissamphibians and other tetrapods, these preliminary results suggest that the conserved relationship between body mass and proximal limb bone circumference could be extended to encompass the majority of quadrupedal terrestrial tetrapods.
No direct bone contact could be seen.
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