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Results: BDL rats had decreased bone mass compared with SO rats as indicated by a 6% decrease in femoral and tibial bone mineral density (BMD), 18% reduction in femoral trabecular bone volume (bone volume/total volume [BV/TV]), 17% decrease in trabecular thickness, and 10% decrease in tibial cortical thickness.
The nonfrail elderly showed greater muscle mass and greater bone mass compared with the prefrail and frail ones.
Men are relatively protected from the development of osteoporosis by a higher peak bone mass compared with women (Campion and Maricic 2003).
But in the control group with no olive oil taken, BMD obviously decreased and t-score categories showed low bone mass compared with the experimental group (P<0.05).
19, 21 In a 6-week ovariectomized rat model, bazedoxifene 0.3 mg/kg/day consistently and significantly increased bone mass compared with control animals.
Skeletal turnover rates appear to be as much as 85% higher in elderly women with low bone mass, compared with women who have normal bone density.
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Vitamin A intake was greater in the groups with normal bone mass compared to groups with low bone mass, with a borderline significance (1239.7 ± 778.6 vs 926.8 ± 819.0 for groups with ≤ 5 years since menopause and 1363.4 ± 1199.4 vs 895.1 ± 871.0 for those with >5 years of menopause; P = 0.051).
Moreover, results from several cross-sectional studies confirmed that both women and men with low bone mass, compared to subjects with normal bone mass, have significantly more subclinical atherosclerosis [ 20, 28, 31- 34, 37, 38, 45, 48, 49, 51, 52, 78, 79], increased risk of peripheral arterial disease [ 28, 29, 34, 54] and other surrogate end markers for CV disease [ 57, 60, 61].
We examined the femur bone mass and found that the aged miR-17 transgenic mice displayed increased bone mass as compared with the wild-type mice.
This genetic approach allowed us to confirm once again that KΔ75 mice had an increased bone mass (21%) compared with WT or Rag1-/ mice.
A greater prevalence of osteophytes has been observed among individuals with high bone mass (HBM) compared with controls.
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