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In addition, the 200 mg/kg dose increased the comparative bone mass compared to that in the osteoporosis model group.
Although the mice seemed normal at birth, after about 3 months they had less bone growth and bone mass compared to normal mice.
DAP12-/ mice had a baseline BV/TV of approximately 30% at the LVB, a doubling of bone mass compared to WT mice (p<0.001).
Serum leptin and total non-esterified fatty acids (NEFA) were elevated in HFD rats, which also had reduced bone mass compared to LFD-fed animals.
To achieve this goal, we analyzed vertebral bodies of 24 weeks old Krm2-deficient mice, since the previous analysis of tibia sections at the age of 12 weeks did not reveal a significant increase of bone mass compared to wildtype littermates [38].
However, the radiographs of the entire femurs and the three-dimensional computed tomography (3-D CT) of the distal femurs revealed that Gsk-3β+/– mice showed an increased bone mass compared to the wild-type Gsk-3β+/+ littemates (Fig. 1B, C).
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Henderson et al (2006) conducted a study to determine whether risedronate is safe and effective in preserving bone mass compared with calcium alone in IBD patients with low bone mass.
Skeletal turnover rates appear to be as much as 85% higher in elderly women with low bone mass, compared with women who have normal bone density.
As in the bone, oim mice also began treatment with ACVR2B with a significant deficit in muscle mass compared to their WT littermates.
Results: BDL rats had decreased bone mass compared with SO rats as indicated by a 6% decrease in femoral and tibial bone mineral density (BMD), 18% reduction in femoral trabecular bone volume (bone volume/total volume [BV/TV]), 17% decrease in trabecular thickness, and 10% decrease in tibial cortical thickness.
The nonfrail elderly showed greater muscle mass and greater bone mass compared with the prefrail and frail ones.
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