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They concluded that risedronate should be considered for the treatment of decreased bone mass associated with Graves' disease.
Recent data indicate that low bone mass associated with CD correlates with the basic pathology of CD rather than malabsorption or complications of steroid treatment [ 22, 23].
Runx2 deficiency in chondrocytes causes enhanced adipogenic differentiation, while PPAR γ haploinsufficient mice show an increase in bone mass associated with a loss of adipose tissue volume.
In rat, treatment with PTH for 12 months produced a dose-related gain in cortical and trabecular bone mass, associated with increased bone strength.
It is unknown whether osteoclast activity (which in these almost mature animals would have been responsible for the lower bone mass associated with disuse) is similar in timing or extent in the different groups, even though it has been shown that Lrp5 HBM+ and Lrp5 −/− mice show no differences in their osteoclast number compared with WT controls [14,15].
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To ascertain whether increased bone turnover in depot medroxyprogesterone acetate (DMPA) users after peak bone mass is associated with bone mineral loss.
Radiological analysis of tibiotarsal bone in six-week-old Pekin domestic duck has shown that lowered bone mass was associated with bone deformities and fractures [ 31, 32].
The increase in bone mass was associated with increased bone formation measured by serum bone formation markers, P1NP and surface-based bone formation rate, BFR/BS.
The investigators reported that a higher bone mass was associated with higher surface-based bone formation rates that were assessed in 24-week-old PRKO mice compared to control animals.
In contrast, among postmenopausal women, exposure after the age of peak bone mass was associated with evidence of better bone structure, though estimates should be interpreted with caution given the small sample size.
Discovery of this association between mutation of the Lrp5 gene and high bone mass occurred around the same time as the realisation that osteoporosis pseudoglioma syndrome (OPPG), a rare autosomal recessive condition characterised by low bone mass, was associated with a loss of function mutation in the same Lrp5 gene [9].
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