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But more crucial organs, including the heart, lungs, gastrointestinal tract and bone marrow, will be at immediate risk.
Therefore, the likelihood that the radiation dose absorbed by susceptible tissues such as gut and bone marrow will be lower and that more radiation dose will be absorbed for longer within the confines of the shrinking tumour favours 177Lu-DAB4 rathan than 90Y-DAB4 for La-targeted RIT post-chemotherapy.
Hillary's next hurdle will be a bone marrow transplant where bone marrow will be taken from a complete stranger and injected into Hillary.
The consequences of residual JAK2V617F burden in the bone marrow will be important to characterize further.
However it is doubtful that sampling of the bone marrow will be possible in such a longitudinal follow up study.
Furthermore, frequencies of systemic tumor reactive T cells in blood and bone marrow will be correlated with clinical outcome.
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If the clinical trial assay will be assayed from more than one tissue, each sample type (e.g., tumor tissue, plasma, and bone marrow) will need to be validated since the preservation method may influence analyte abundance.
Subsequently, early c-kit positive progenitor cells will detach from the bone marrow niche, move to the vascular zone of the bone marrow and will be released in the circulation [ 62].
In depth research into the functional role of bone marrow adipocytes will be important for uncovering age related changes in bone, hematopoiesis and metabolic functions.
T1-weighted spin echo (SE) sequences will assess fat distribution within the bone marrow, which will be compared to the normal age-related distribution of fatty marrow.
In a separate protocol bone marrow micrometastasis will be analyzed.
More suggestions(15)
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