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With unadulterated Wnt in hand, the researchers added the protein to mouse stem cells from bone marrow, which generate a range of blood and immune cells.
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The stem cell transplantation is used to kill off the patient's old bone marrow, which produces the harmful cells that cause the Crohn's, and generate new cells.
Roberts' disease involves damaged bone marrow, which carries a high risk of developing into leukemia.
Blood is produced in the bone marrow, which is one of the organs that is most vulnerable to radiation.
In order to investigate if the failure to grow in the mouse organs is due to the inability of the mutant to survive inside the macrophages, we examined the growth and survival of the mutant in resting and IFN-γ activated murine bone marrow derived macrophages which generate an oxidative burst by producing ROS and RNS [37].
Bone marrow contains cells called hematopoietic stem cells, which generate all the cell types of the blood and the immune system.
Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced.
Once there, MSCs contribute to the development of an active TME, in which bone marrow-derived MSCs generate CAFs, while local adipose tissue-derived MSCs contribute mainly to the vascular and fibrovascular stroma (pericytes, myofibroblasts, and ECs) [ 186].
Multiple myeloma (MM) develops and expands almost exclusively in the bone marrow and generates devastating bone lesions.
Previous suggestions indicated that recruited bone marrow progenitor cells generated a premetastatic niche to which the cancer cells metastasize [ 9- 11].
Bone marrow chimeras were generated using the Ly5.1/5.2 reconstitution system, as previously described [6].
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