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Total number of cells in bone marrow was calculated by multiplying the number of cells from two femurs ×7.9 [69], [69].
The absorbed dose to the bone marrow was calculated.
For all patients the absorbed radiation dose to the bone marrow was calculated according to the MIRD scheme (Eq. 1).
Therefore it was not possible to place a ROI reliably, and consequently no absorbed dose to the bone marrow was calculated from SPECT scans.
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The radiation dose to the bone marrow is usually calculated according to the MIRD scheme, where the accumulated activity in the bone marrow is calculated from the accumulated radioactivity of the radiopharmaceutical in the blood.
The absorbed radiation doses to dose-limiting organs such as the kidneys and bone marrow are calculated to better tailor the total cumulative activity that can be administered to the individual patient.
For the bone marrow, all bony structures in the field of view were segmented and the bone marrow dose was calculated as the weighted sum of the doses to these structures with the percentage of bone marrow in these compartments as weighting factor [ 21].
The total number of bone marrow cells was calculated based on the assumption that both femoral bones contain approximately 8% of total bone marrow cells [ 16].
Bone marrow SUVmean was calculated by averaging the values of elliptical VOIs with a volume of 2 to 5 cm3 allocated in both iliac crests and spherical VOIs with a volume of 1 to 1.5 cm3 in each lumbar vertebral body.
A three-material decomposition (bone, red bone marrow, yellow bone marrow) was performed for each voxel.
Bone marrow was removed with saline lavage.
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