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For patients with lymphoma that recurs after chemotherapy, bone marrow transplantation using cells from a healthy donor represents potentially curative treatment.
We have assembled clinical and scientific researchers throughout the state of California to study and compare bone marrow transplantation using our new approach with the best standard of care chemotherapy in AML patients over the age of 50.
Innovative programs pioneering bone marrow transplantation using publicly donated umbilical cord had their start at Duke Medical Center.
These experiments were compared to allogeneic and syngeneic bone marrow transplantation using 2×106 cells.
In this study we investigated fusion and trogocytosis involving blood cells during bone marrow transplantation using a xenograft model.
We have demonstrated that during bone marrow transplantation using an irradiation pre-conditioning the frequency of trogocytosis and the different types of cells involved greatly increases.
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Subsequently, we performed bone marrow transplantations using either wild type mice (PLTPwt/wt), hemizygous PLTP transgenic mice (huPLTPtg/wt) or homozygous PLTP transgenic mice (huPLTPtg/tg) as donors and low density lipoprotein receptor deficient mice (LDLR−/−) as acceptors, in order to establish the role of PLTP expressed by bone marrow derived cells in diet-induced atherogenesis.
These stem cells play critical roles in the generation, repair, and homeostasis of the blood and immune system and are the main component in bone marrow transplantations used to treat a number of hematologic diseases such as leukemia, bone marrow failure syndromes, and anemia.
After 6 8 weeks, recipient mice were bled from the orbital sinus to evaluate bone marrow transplantation efficiency using flow cytometry.
We performed bone marrow transplantation (BMT) using transgenic C57BL/6J mice producing the enhanced green fluorescent protein (EGFP) as donors to db/ db mouse recipients.
Regardless whether PBSCT or autologous bone marrow transplantation is used, it is crucial to eliminate leukaemic cells from the transplant in order to avoid the transfer of leukaemic cells back to the patient.
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