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The clinical significance of the standard bone marrow tests is well understood but, since the trial was investigating the stratification of treatment on the basis of MRD results, understanding the significance of the MRD test was part of the trial's rationale.
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Cripe said that a morning examination showed that Pagano's white blood cell count and bone marrow tests were normal as he prepared to start a second round of chemotherapy.
If this was the case, a bone marrow test was taken to confirm the return.
Then a bone marrow test was taken to confirm it, or not, and the test result was given to the patient (C: 10, E: 9).
When the relapse was confirmed by a bone marrow test, it was what the patient had already suspected (E: 9).
Now, she expected a bone marrow test, as before, to be taken to confirm her state of health as terminal.
Despite the oxidative metabolism of these compounds and the production of oxidative adducts, their genotoxicity in the bone marrow micronucleus test is unclear.
Bone marrow puncture test was normal.
The rodent bone marrow MN test was most widely used as an in-vivo assay for identification of genotoxic effects of different carcinogenic agents [ 19, 20].
Neilson underwent chemotherapy and a stem-cell transplant, but won't know for sure if the cancer is in remission until his bone marrow is tested in a month or so.
The frequency of cytogenetic chromosomal aberrations, such as translocations and hyperdiploidy in this group of leukemia cases, could not be compared with the frequency of these aberrations found in the general population of children with ALL because, in most cases, bone marrow was not stored, testing was not done, or cells did not divide for metaphase analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com