This results in a number of side effects: Bone marrow suppression: Chemotherapy can suppress bone marrow, causing the cat's white cell count to fall.
In the bone marrow, OVX suppressed granulocyte and committed monocyte populations and increased the lymphoblast population, but the MDP and HDP restored these myeloid and lymphoid populations to the level of the Sham.
Further reduction of pO2 to <10 mmHg, equivalent to the bone marrow endosteum suppresses both differentiation and proliferation of ESCs while retaining pluripotency [ 7, 8].
Previously nonobese diabetic (NOD) HIIE α-HSP60 Tg mice, in which HSP60 is driven by the MHC class II-E α (HIIE α) promoter, achieved HSP60 expression specifically in the thymus and bone marrow and suppressed susceptibility to autoimmunity induced DM [ 31].
Second, cytokines may act directly on differentiation of bone marrow stem cells, suppressing erythropoiesis and leading to anemia of inflammation [ 59].
Bone marrow MSCs suppress T-cell activity and therefore avoid allogeneic rejection, and because of their plasticity, they are able to form new joint tissues and secrete bioactive factors providing a regenerative environment (trophic activity) that stimulates tissue-intrinsic repair cells or stem cells (reviewed in [ 8]).
In addition, all non-bone marrow populations suppressed mitogen-induced T-cell proliferation at levels comparable with BM-MSCs, and, at least in part, by similar mechanisms [ 99].
In this study, both FM550 and TPP suppressed osteogenesis in bone marrow cultures, with FM550 suppressing activity more than TPP alone.
Thiopental is another intravenous anaesthetic used in intensive care patients, usually for the management of patients with refractory status epilepticus or intracranial hypertension [1], but again can impair immune function, for example by suppressing bone marrow haematopoiesis [3].
During the course of the CCHF disease, the excessive release of proinflammatory cytokines decreases the neutrophil, lymphocyte, and platelet counts by suppressing bone marrow and stimulating hemophagocytosis [ 16].
Cantharidin has an affinity for the liver [ 6], and has demonstrated therapeutic effects against HCC in clinical trials without suppressing bone marrow function, even in patients at an advanced stage [ 6, 7].
