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The standard procedures for chondral defects in the knees – where we cannot expect spontaneous healing – are the bone marrow stimulating techniques such as microfracture and drilling, mosaic plasty, autologous chondrocyte implantation developed by Dr. Peterson and Dr. Brittberg et al. and our tissue-engineered cartilage transplantation.
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These common repair techniques comprise debridement, bone marrow-stimulating techniques, osteochondral grafting, and autologous chondrocyte implantation (ACI) [ 2- 5].
In the clinical routine, debridement, bone marrow-stimulating techniques, osteochondral autograft transfer, and autologous chondrocyte implantation (ACI) are commonly used cartilage repair techniques [ 4- 8].
Microfracture technique belongs to the bone marrow stimulating methods like abrasion arthroplasty or subchondral bone drilling.
This presents a potential difficulty in assessing the bone marrow of younger patients and patients receiving bone marrow-stimulating factors after CR [26].
Bone marrow stimulation.
Stem cells collected from the patients' bone marrow were stimulated to produce NTFs.
EPO help form red blood cells by stimulating bone marrow to produce them.
The two drugs stimulate bone marrow to produce more oxygen-carrying red blood cells.
The anemia drugs are proteins that stimulate bone marrow cells to produce hemoglobin, the main component of red blood cells.
Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts.
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