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Evaluation by the more sensitive deep-sequencing method revealed a known activating mutation, L1679P, in exon 27 of NOTCH1 in the T-ALL patient with a CR, which was confirmed in an independent bone marrow sample collected at a different time point (25% blasts; Table 2).
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Bone marrow samples collected from 52 patients after high-dose therapy were examined to evaluate the prognostic relevance of isolated tumour cells.
Sixteen bone marrow samples collected at diagnosis from patients with childhood acute lymphoblastic leukemia (ALL) were analyzed in this study (Additional file 1: Table S1).
Bone marrow aspirates collected at diagnosis of ALL and matched germline peripheral blood or bone marrow samples collected in first continuous complete remission (CCR1) from four patients were subjected to whole genome sequencing (WGS) (Table 1).
Bone marrow mononuclear cells from a 73 year old healthy female were taken from a biobank of human bone marrow samples collected from the proximal femur during hip replacement surgery.
In addition, the good preservation of many of the bone marrow samples collected up to 5 hours postmortem suggests that significant autolysis may not occur as quickly in this species as compared to others.
Blood and bone marrow sample was collected in heparinized tubes.
The hearts, livers, spleens, and ears were collected from the same set of three individuals of each strain and bone marrow samples were collected from three additional sets including three animals of each strain.
Bone marrow samples were collected from the lesion site (P) and the iliac crest (IC) of 7 patients affected by CPT and type 1 neurofibromatosis (NF1+) and 6 patients affected by CPT without NF1 (NF1−).
Long bone marrow samples were collected, dried, and the % marrow fat calculated by this method.
Bone marrow samples were collected at week 4 and 5 after reconstitution, at which time mature T cells were not detected in the periphery and there were no signs of immunopathology in the crt−/− FLC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com