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Intense increased FDG uptake is commonly observed in the bone marrow and spleen following GCSF therapy; however the bone marrow response to GCSF can be differentiated from pathological infiltration by its intense homogeneous nature without focally increased areas of FDG uptake.
Acute clinical malaria has been associated with a reduction in STfR measurement [12] and a rapidly reversible suppression of bone marrow response to EPO [13].
Chronic inflammation seems to play a role in some patients and there is evidence that inflammatory cytokines may down regulate the bone marrow response to erythropoietin [10], [11].
The MRI/PET changes reflect the bone marrow response to treatment.
HIV infection did not seem to affect the bone marrow response to stimulation by EPO, i.e., TfR increased in direct response to increased EPO levels, at all ages.
In the current study, MPV, PDW, and P-LC Rwere higher in the HCV-infected group than in the control group, which indicates that large platelet formation is an inappropriate bone marrow response to thrombocytopenia.
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The free concentrations in the bone marrow from the liposome leak in plasma could also be predicted using the bone marrow responses to the conventional drugs.
Remarkably, G-CSF fails to mobilize endothelial progenitor cells in mice not bearing tumors suggesting modulatory effects of tumor microenvironment on bone marrow responses to cytokines 20.
15 This imaging technique has been validated in Gaucher disease as an instrument to evaluate bone marrow responses to treatment, and increases in fat fractions over 12 24 months can typically be observed.
Clinical characteristics of patients according to bone marrow response on day 15.
Age, leukocyte count and early response to treatment defined by the D21 bone marrow response provide an accurate model for outcome prediction.
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