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Surprisingly little is known about how these terminal stages of erythropoiesis are matched by bone marrow production of more immature erythroid progenitor cells.
In IL7−/− mice, bone marrow production of B cells ceases after 8 weeks of age, while a pool of mature B cells is sustained that has been proposed to derive from IL7-independent fetal or perinatal precursor B cells [21] [35].
Neither did we evaluate whether bone marrow production of neutrophils was altered by the therapy.
Leukopenia is characteristic of dengue virus and has been associated with suppression of bone marrow production (6 ).
The analyses utilise a semimechanistic model proposed by Friberg et al (2002), describing the effect of cytotoxic drugs on bone marrow production.
The etiology of anemia of critical illness is multifactorial; it often results from a combination of primary losses, abnormal coagulation, nutritional deficiencies, depressed bone marrow production, and phlebotomy.
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We conclude that thrombocytopenia in ponies acutely infected with EIAV is regenerative and suggest that bone marrow platelet production is not severely compromised in these ponies.
In bone marrow, monocytic production appears to be under the influence of sympathetic activation via β2-receptors.
Interestingly, T cell-deficient nude mice, CD40-deficient mice, and CD40L-deficient mice displayed osteoporosis and diminished bone marrow OPG production [ 71].
Multiple myeloma (MM) is a plasma-cell malignancy characterized by accumulation of malignant cells in the bone marrow and production of a monoclonal immunoglobulin (M protein).
On the other hand, we have recently characterized two distinct mechanisms, operative in vivo, which effectively prevent the stimulatory effect of lung immune responses on bone marrow eosinophil production.
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