Sentence examples for bone marrow of old from inspiring English sources

However, the mechanisms which heighten apoptosis in the bone marrow of old mice remain to be determined.

Not only are immature B cells in the bone marrow of old mice more reactive with PC, but so too are splenic B cells (Zharhary & Klinman, 1986).

However, this age-related impairment in phagocytosis was not observed in bone marrow-derived macrophages (BMDMs) or monocytes isolated directly from bone marrow of old mice, indicating no intrinsic defect in phagocytosis in macrophage progenitors in this model.

iPSCs generated from bone marrow of old mice (23 months old) were more difficult to produce than those generated from the bone marrow of young mice (2 months old), requiring twice as much time to reprogram (Cheng et al., 2011).

We and others have shown that a novel mature B-cell subset, the 'age-associated B cells (ABC)', accumulates in the spleens as well as the bone marrow of old mice (Hao et al., 2011; Ratliff et al., 2013) while follicular (FO) B cells decline.

Studies conducted in mice have identified decreased frequencies of common lymphoid progenitors (CLP / early B cell progenitors (EBP), pre-pro B cells, pro-B cells, and pre-B cells in the bone marrow of old mice [ 71, 73- 75], which are due in good measure to cell-intrinsic changes in HSC [ 36, 50].

In particular, osteogenesis is dominant over adipogenesis in the bone marrow derived MSCs of younger adults, while this balance is usually reversed in the bone marrow of older adults including patients with osteoporosis [11], [12].

Furthermore, competitive repopulation assays in murine transplantation models demonstrated that bone marrow of older mice had a higher number of ST-HSC and progenitor cells [ 32, 33].

Comparing 3 and 12 months old WT, CD137−/− and CD137L−/− mice we found significantly more granulocytes and monocytes in the bone marrow of older WT mice, while this age-dependent increase was absent in CD137−/− and CD137L−/− mice.

In vivo, multiphoton intravital microscopic analysis of HSC in the bone marrow of young and old mice has revealed that old HSC reside further away from the endosteum than young HSC progenitors, indicating age-related extrinsic changes in niche composition that could impact HSC function [ 30].

There was also a general increase in the number of CD137− CD4+ T cells in the bone marrow of 12 months old mice in all three strains compared to their 3 months old controls.