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This approach aims to increase the therapeutic efficacy by reducing the terminal half-life of antibodies or Fc-containing antibody constructs, thus reducing the dose-limiting toxicity to the blood and bone marrow of intact radiolabelled therapeutic antibodies.
First, we analyzed the bone marrow of intact Rgs5 gfp/ +mice.
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The number of stromal fibroblastic progenitors (CFC-f) in the bone marrow of these rats was also reduced.
For bone metastasis model two cohorts of NSG mice (castrated and intact) received orthotopic injection of VCaP-Luc cells into the bone marrow cavity of left tibia.
No differences have been observed between osteoclast cultures derived from intact mice and those derived from corresponding bone marrow chimeras of either genotype (data not shown).
Hence, it is conceivable that under these therapies, the bone marrow environment remains widely intact.
Tumorous bone marrow infiltration of less than 1% was diagnosed in bone marrow specimen.
Copyright is the bone-marrow of the western intellectual tradition.
It is much harder to match types of bone marrow than types of blood.
Another letdown was an appetizer of "bone marrow flan" that deprived marrow of its oozing glory.
Acute lymphocytic leukemia, or ALL, is a cancer that arises in the bone marrow, the soft center of flat bones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com