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On the other hand, growth-factor-deficient conditions may occur to leukaemic cells in vivo when stromal functions are severely damaged after intensive chemotherapy or bone marrow occupation by malignant cells (Ben-Ishay et al, 1990).
We propose that recurrent growth factor starvation, which may occur in vivo when stromal function is damaged after intensive chemotherapy or bone marrow occupation by malignant cells, causes selection of drug resistant leukaemia cells that will expand when the growth factor supply recovers.
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