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Red bone marrow has a lower adiposity and higher water content, which contributes to the higher signal intensity on b-value images and higher ADC values [16, 26] (Fig 6).
Although displaying the same pattern of expression where GNAS, SNRPN and IGF2R are most highly expressed, bone marrow has a lower level of expression of imprinted genes compared to PBL (Tables 1 and S1).
The erythropoetic compartment of bone marrow has a high expression level of the transporter TFR1 and rapidly integrates iron into hemoglobin [ 13, 14].
Our results are in agreement with a recent study reporting that aged bone marrow has a reduced frequency of proliferating immature NK cells (Beli et al., 2014).
The most recent studies [ 2- 7] consistently reported that the presence of DTCs in bone marrow has a strong prognostic impact on patient survival.
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Patients who received transplants when they had fewer blasts in their bone marrow had a decreased chance for disease recurrence when compared with patients with excess blasts.
One hundred seventy out of every 200 cells in his bone marrow had a cancer-causing mutation, and his lymph nodes were swelling, a sign the cancer was getting worse.
In some cases, the detection of tumor cells in the bone marrow had a superior prognostic value or clinical significance compared to detection of CTC in blood (Pierga et al. 2004).
The lymphocytes generated in the bone marrow have a high diversity with respect to their receptors, due to alternative splicing, which is somatic rearrangement of noncontiguous genomic V, J, and C regions, and sometimes hypermutation.
Aged WT bone marrow had a significant increase in adiposity.
Patients with RT-PCR negative bone marrow had a significant better overall survival; HR 6.40, 95% CI 1.93-21.16, p = 0.002.
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