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If RT is administered to several areas, or briefly after chemotherapy, impairment of bone marrow function can be observed including anemia, low platelets count, and decreased level of white blood cells in peripheral blood.
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The antiretroviral (ARV) zidovudine (ZDV) affects bone marrow function and can cause or exacerbate pre-existing anaemia, in addition to its classical manifestation of macrocytosis [ 17- 20].
23 There are also reports of other hematologic cytopenias in patients receiving other TNF antagonists, though often in combination with drugs that can suppress bone marrow function.
Unfortunately, both agents can cause substantial myelosuppression, thus prohibiting their use in patients with inadequate bone marrow function.
Adequate hepatic, renal and bone marrow function were required.
– Inadequate bone marrow function to undergo planned therapy.
Renal and bone marrow function were then monitored during treatment.
Bone marrow function was assessed by complete blood counts (CBCs) as well as microscopic bone marrow examinations.
Normal cardiac, renal and bone marrow functions were required.
Here, we first review several observations showing that the bone marrow can function as a secondary lymphoid organ for both CD4 and CD8 cells, as well as a preferential homing site for memory T cells.
It is well established that the interactions of HSCs with the bone marrow microenvironment can significantly influence their function and fate [17].
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