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It arises in bone marrow from malignant B-lymphoid progenitors.
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Bone marrow transplant, the transfer of bone marrow from a healthy donor to a recipient whose own bone marrow is affected by disease.
I decided to study a bone marrow malignant disease called myelodysplastic syndromes (MDS), which frequently evolves into acute leukaemia, back in the early 1980s.
Bone marrow specimens from patients with malignant haematological disease, that is, 10 non-Hodgkin's lymphomas (NHL), five multiple myeloma (MM) and two acute myeloid leukaemias (AML), were also tested for the MAM and maspin transcript expression.
In a set of experiments we used bone marrow aspirates from unrelated, non-malignant diseases artificially contaminated with a known number of gastric cancer cells taken by fine needle aspiration biopsy from surgical specimens to determine the sensitivity of our immunocytochemical method in the detection of cytokeratin-reactive tumour cells as previously reported in detail (Pelosi et al, 1999b).
Up to now, bone marrow samples from more than 200 patients without malignant disease have been examined, with a false positive rate of 1% [ 25].
Bone marrow aspirate revealed no malignant cells.
In six cases (31.6%), malignant cells were identified in both bone metastasis and bone marrow samples from the same patient.
Seven bone marrow aspirates obtained from patients with malignant lymphoma without bone marrow infiltration were used as control samples.
Furthermore, dasatinib has shown promising in vitro activity against malignant bone marrow cells isolated from patients with imatinib-resistant CML.
As control tissues, we used bone marrow (BM) aspirates from individuals with non-malignant disease that contained no neoplastic cells.
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