Sentence examples for bone marrow failure and from inspiring English sources
He had severe bone marrow failure and gut damage, which fitted.
Dr. Greider acknowledged that solid evidence showed that the 1 percent of people with the shortest telomeres were at an increased risk of certain diseases, particularly bone marrow failure and pulmonary fibrosis, a fatal scarring of the lungs.
In the most severe cases, compromised renewal of hematopoietic stem cells leads to bone marrow failure and premature death.
ATM-deficient (ATM−/−) mice show progressive bone marrow failure and impaired HSC self-renewal due to an elevated level of reactive oxygen species (ROS) (Ito et al., 2004).
Most importantly, the surviving double knockout (FancD2−/−Aldh2−/−) mice developed a typical FA phenotype with various malformations, progressive bone marrow failure, and death due to leukemia.
Defects in telomere length homeostasis and telomerase activity are associated with numerous human diseases including progeroid syndromes, cancer, bone marrow failure, and pulmonary fibrosis [6].
Further mouse models will be required to elucidate the role of apoptosis susceptibility or resistance, respectively, for pathogenesis and progression of bone marrow failure syndromes and MDS to AML.
Invasive fungal infections are important causes of morbidity and mortality in patients with bone marrow failure syndromes and hematological malignancies, or who are undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
Clinical manifestations of WM include lymphoma-related lymphadenopathy, organomegaly, fatigue, disease related fever, or symptoms related to bone marrow failure (cytopenias) and IgM-related cryoglobulinemia, cold agglutinin syndrome, demyelinating neuropathy, and symptomatic hyperviscosity [ 3].
Chronic Lymphocytic Leukemia (CLL) is immunophenotypically defined as a malignancy of CD5/CD19/CD23 positive, CD20 and Ig dim B cells that manifests with bone marrow failure, lymphadenopathy and infections as a consequence of disease-associated immune suppression.
Such growth failure is therefore sufficient to consider a diagnosis of LIG4 deficiency and early recognition of such cases is important as bone marrow failure, immunodeficiency, and sometimes malignancy are long term sequelae of this disorder.
