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Considering that we utilized zebrafish grown under specific pathogen free conditions and the cells used were from the bone marrow equivalent in fish, the possibility of low expression of MR in these cells could account for the lack of mannan inhibition and the apparent uptake of FITC-DX by macropinocytosis alone.
Interestingly, the kidney (bone marrow equivalent) did not express NLR-A3 as well suggesting that it is not expressed by lymphocytes (data not shown).
Head kidney (bone marrow equivalent of fish) and peritoneal exudate cells were obtained 4 h and 24 h after bacterial challenge.
Increased cmyb- and runx1-positive HSPCs were also found in the caudal hematopoietic tissue (or CHT, akin to mammalian fetal liver) and the pronephros, which matures into the kidney marrow, the mammalian bone marrow equivalent.
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Recent advances in engineering complex organs in vitro inspire the development of human bone marrow equivalents to foster scientific discovery and innovative therapeutics.
In this experiment, we have hypothesized that the concentration of G-CSF in the bone marrow was equivalent to that in the serum.
Importantly, this study demonstrated that fresh or cryopreserved cells from sources such as normal or malignant (acute myelogenous leukemia, chronic lymphocyte leukemia) peripheral blood, cord blood or bone marrow yielded equivalent results.
Our data demonstrates that loss of PECAM-1 does not affect the homeostatic balance of HSCs in the bone marrow, resulting in equivalent numbers of both KSL and total mature cells of all lineages.
EPOR transcript levels in tumours and tumour cell lines were low in comparison with bone marrow and were equivalent to, or lower than, levels in normal tissues of tumour origin.
The number of PCNA-positive cells in the stimulated and stationary bone marrow cavities was nearly equivalent at the 72 h time point (Fig. 3A,B).
In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown.
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