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Beclin 1-chimeras had greatly reduced numbers of early B cells in the bone marrow compared with controls, while the peripheral B cell compartment was normal [45].
Moreover, levels of 1,25 hydroxyvitamin D (the active form of vitamin D) are several hundred-fold higher in bone marrow compared with plasma [ 14].
Furthermore, levels of 1,25 hydroxyvitamin D (1-25(OH)D), the active form of vitamin D, are several hundredfold higher in bone marrow compared with plasma [ 25].
In addition, expression of genes involved in fatty acid synthesis and fatty acid oxidation were lower in bone marrow compared with epididymal adipocytes, whereas genes associated with decreased mitochondrial function, such as TNFα, p53, BCL2L11 and IL-1β, were significantly higher in bone marrow compared with epididymal adipocytes.
Inhalation exposure to mainstream smoke for up to 13 weeks did not increase the incidence rates of micronucleated reticulocytes in circulating blood, nor micronucleated erythrocytes in bone marrow compared with sham-exposed controls (data not shown).
Like BP-2 mice, BALB/c submitted to oral tolerization followed by sensitization and challenge (OVA/OVA/OVA) presented significantly reduced EPO+ cell counts in freshly harvested femoral bone marrow, compared with nontolerized H2O/OVA/OVA controls).
Similar(49)
Yellow bone marrow has low signal intensity and low ADC values probably because of the reduced proton density, the hydrophobic nature of fat and lower bone marrow perfusion (compared with red bone marrow).
Five of the 7 p80HT mice developed plasma cell tumors and became moribund within one and half years, and two of them (#6698 and #7453) had a marked increase in the bone marrow plasma cell content (>10% of the total bone marrow cellularity) compared with <2% for their WT littermates.
There is increased F-FLT uptake in the bone marrow areas compared with that in healthy control subjects and a significant expansion of the bone marrow compartment in patients with MDS (Fig. 4b).
As expected, in this study Dex or Dex + Ral treatment resulted in a significant reduction of CD19+ bone marrow cells compared with controls, while there was only a tendency towards a reduction of CD3+ bone marrow cells.
Bone marrow aspirates were drawn in 15 patients after treatment with [Lu-DOTA,Tyr]octreotate. Radioactivity in the bone marrow was compared with radioactivity in the blood drawn simultaneously.
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