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Total bone marrow cellularity was also determined at day 14.

Bone marrow cellularity was normal with brown pigment (likely hemosiderin) and an absence of hemophagocytosis.

Although the overall bone marrow cellularity was not significantly different, we confirmed a significant reduction in recirculating mature B cells in the TACI-Ig mice (Supplementary Table 1).

Further analysis also showed that the number of bone marrow cells that could be obtained from Dnmt2−/− femora was reduced by 20%, indicating that the bone marrow cellularity was significantly (P < 0.05, t-test) reduced in Dnmt2−/− mice (Fig 1D).

Maturation index ratios relating to bone marrow cellularity were calculated with the aim of evaluating bone marrow response in dogs naturally infected with L. chagasi and exhibiting different clinical statuses and patterns of bone marrow parasite density (Table 2).

Although no changes in bone marrow cellularity were observed in mice treated with HQ, cellularity was decreased by a factor of two in the mice that had received HQ plus PHE.

In order to evaluate bone marrow responses in dogs naturally infected with L. chagasi and showing different clinical statuses and patterns of bone marrow parasite density, numerical assessments of bone marrow cellularities were made on the basis of the maturation index ratios defined by Hoff et al. [20] and Mischke et al. [21] (Table 1).

Microvessel density, fibrosis, bone growth and marrow cellularity were normalised after plitidepsin treatment of the mice and extramedullary haematopoiesis did not develop in liver; notwithstanding, the abnormally reduced CXCR4 expression in Gata-1 low) Gata-1 low cells was not improgenitorplitidepsin.

Microscopic analysis looks at osteoid formation, area occupied by osteocytes and bone marrow cellularity, which are important for long-term bone graft union at graft-host junction.

In the presence of BD extract the effect of radiation on bone marrow cellularity can be seen by only 46% reduction in cellularity compared with 68% reduction in radiation alone.

Bone marrow contains hematopoietic stem cells and stromal cells (mostly adipocytes) [ 8], and marrow cellularity is the volume ratio of hematopoiesis and fat.