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We found that bone marrow cell migration into pancreatic tissue was restricted vs. migration into the spleen, as shown figure 3 (about 120 folds difference).
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The mechanisms involved may rely on cellular surface chemokine receptor expression and pancreatic islet releasing factors, in which activation of chemokine receptors in bone marrow cells promotes cell migration into the islets [15] [17].
Platelet concentrates play an important role in the bone tissue reparative processes by stimulating the initial recruitment of bone marrow cells for migration [ 7], mitogenesis, differentiation into osteoblasts, and angiogenesis [ 8].
BMC: bone marrow cell.
Similarly, migration of bone marrow cells (BMCs) to sites of myocardial infarction can be induced by incorporation of CXCL12 into HA hydrogels implanted into the infarction sites.
Recent research indicates that YGJ improved liver fibrosis by inhibiting the migration of bone marrow cells into the liver, inhibiting their differentiation and suppressing the proliferation of both progenitor cells and hepatocytes in injured livers [ 6].
Hamamoto et al. reported that G-CSF promoted the migration of bone marrow cells to diseased hearts and also directly enhanced the proliferation of troponin I-positive cardiomyocytes via G-CSF receptors on the cardiomyocytes [ 23].
There is a current trend towards agreement that percutaneous techniques that create mechanical disruption of the cyst membrane, concomitant migration of bone marrow cells for osteoinduction, and the use of calcium sulfate substitute for osteoconduction yield better outcomes when compared with other treatments.
Thus the defect in migration of PECAM-1−/ PECAM-1−/row cells appears to be specific to CXCL12.
Bone marrow cells from rats and human embryonic brain cells show a facilitated cell migration [ 153, 154], while bone marrow CD34+ cells have a lower migration potential in simulated microgravity [ 155].
Control mice received bone marrow cells only.
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