Notably, ETV7 is upregulated in a variety of different human cancers and, when introduced into murine bone marrow, can cooperate with other oncogenes to cause hematopoietic malignancy.
In rare cases, patients can develop a chloroma, or solid tumor of leukemic cells outside the bone marrow, which can cause various symptoms depending on its location.
Studies have shown that chronic erythrocyte depletion in the bone marrow and spleen can cause an impaired stress response and trigger anemia in mice [22].
The antiretroviral (ARV) zidovudine (ZDV) affects bone marrow function and can cause or exacerbate pre-existing anaemia, in addition to its classical manifestation of macrocytosis [ 17- 20].
However, it has been suggested that antigenic challenge, at least in the bone marrow of mice, can cause a switch from κ-light chain to λ-light chain, which indirectly may support our findings [ 17, 18].
A disease of bone marrow failure, the condition can cause skeletal deformities and increases cancer and anemia susceptibility.
Known leukemogens, such asbenzene, can cause bone marrow toxicity, which affects the ability of bone marrow cells to produce blood-forming cells (ATSDR, 2007).
Megan was born with Fanconi Anaemia, a rare inherited condition which can cause bone marrow failure.
"It can cause bone marrow not to produce enough red blood cells, which can lead to anemia," according to the CDC.
Long-term use, however, has been associated with serious adverse effects; linezolid can cause bone marrow suppression and low platelet counts, particularly when used for more than two weeks.
