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17-DMAG is a potential radioprotectant for bone marrow and small intestine that results in survival improvement.
It is, therefore, of great interest to determine whether orally administered 17-DMAG was also radioprotective for survival, bone marrow, and small intestine.
A single dose of orally administered 17-DMAG (10 mg/kg) as a prophylactic measure prior to irradiation was effective to increase mouse 30-day survival by protecting bone marrow and small intestine from radiation injury.
Accordingly, the levels of DNA adducts are highest in glandular stomach and liver, the sites of contact and primary site of metabolism, respectively, and lowest in the bone marrow and small intestine (Fig. 1).
The newly published standardized guidelines for interpretation formulates specific criteria for visual interpretation and for defining PET positivity in the liver, spleen, lung, bone marrow and small residual lesions.
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Furthermore, distributions of these drugs in the bone marrow and the small intestine decreased during artificial hypertension to 60-80% of those in the normotensive state.
The absence of a mouse model that mimics the MKs and platelet defects found in WAS patients, combined with the limited availability of patients' bone marrow and their small number of platelets (Gröttum et al., 1969) have precluded further advances in the understanding of WASP function in MK physiology (Strom, 2009).
However, PC3-N could generally survive no longer than one week in the bone marrow and only a small number of mice showed small skeletal metastases at three weeks post inoculation.
There is physiological FLT uptake in the bone marrow and in the small intestine in the left side of the pelvis.
Adult bone marrow and peripheral blood contain small subsets of mononuclear cells that can be differentiated into endothelial-like cells in vitro.
72 h following the last dose, mice were euthanized, and tissues (glandular stomach, small intestine, bone marrow and liver) were collected for lacZ mutation and DNA adduct analysis, and blood was evaluated for Pig-a mutants.
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