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CXCR4 was, however, even more highly expressed in normal bone marrow and normal lung, two breast cancer metastasis sites, than in the breast tumours studied.
Radiotherapy is usually delivered only to the immediate lesion area, to spare bone marrow and normal soft tissue as far as possible.
The aim of this workshop is to remind the radiologists of the MRI patterns of normal bone marrow and normal variants and to show the effects of treatments on normal bone marrow and treatment related modifications on pathological marrow.
The aim of this paper is to recall the MRI patterns of normal bone marrow and normal variations and to show the effects of treatments on bone tissue and normal bone marrow and treatment-related modifications on pathological marrow.
As expected, non-irradiated adult Lepr cre ; Angpt1 fl/GFP mice, Mx1-cre; Angpt1 fl/fl mice, and Lepr cre ; Mx1-cre; Angpt1 fl/GFP mice all had normal bone marrow cellularity, normal numbers of LSK cells in the bone marrow, and normal CD150+CD48−LSK HSC frequency.
It has been argued that a long-lived radiolabelled antibody might induce bone marrow and normal tissue toxicity, whereby limiting the amount of activity that can be administered, but there have never been any published clinical data reported to support this theory, to our knowledge.
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Osx-cre; Angpt1 fl/fl mice also had normal blood cell counts, normal cellularity, and HSC frequency in the bone marrow and spleen, normal frequencies of colony-forming progenitors in culture and normal levels of long-term multilineage reconstitution upon transplanting bone marrow cells into irradiated mice.
Despite the adverse side effects caused by alkylating agents on bone marrow and other normal tissues, melphalan remains one of the most commonly prescribed chemotherapies in MM patients.
In most patients, induction chemotherapy is initially used to reduce the burden of lymphoblasts in the bone marrow and restore normal hematopoietic function.
Physiological high FLT uptake is seen in the bone marrow and in the normal intestine.
About 80% of children with RCC have a hypocellular bone marrow, and karyotype is normal in the majority of patients.
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