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Bone marrow and cord blood are rich with the cells, but they yield limited amounts.
As such, the bone marrow and cord blood may provide suitable alternatives for the derivation of the stem cells we seek".
MSCs from the bone marrow and cord blood are able to upregulate genes associated with DA neurons such as the orphan nuclear receptor Nurr1 and TH [5], [8] Recently, it was shown that cord blood derived MSCs could differentiate into neurons with functional properties such as the ability to synthesize and release dopamine into the culture supernatant upon stimulation [7].
FL was unable to induce STAT5 phosphorylation in any of the hematopoietic compartments, in agreement with previously published observations [24], even though its receptor FLT3 was highly expressed at the HSC and CMP/GMP progenitor stages in human CD34+ cells from both bone marrow and cord blood [31].
Mesenchymal stromal cells (MSC) are found in all supportive tissue as in fat tissue, bone marrow and cord.
Previous studies have demonstrated the various proliferation effects of CCL19/CCL21 on human M cells, CD4 and CD8 T cells, bone marrow and cord blood CD34+ cells [ 15, 27, 29– 31].
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Last year the national registry helped bring about transplants from unrelated donors to more than 2,800 recipients: 1,700 peripheral blood stem cells, 821 bone marrow and 324 cord blood transplants.
Stem cells found in bone marrow and umbilical cord blood have long been used to successfully treat some cancers, and blood and immune diseases, but those are among the few proven treatments.
As surrogates for cellular components of the niche, mesenchymal stem cells (MSCs) from different sources (bone marrow and umbilical cord) and osteoblast-like cells were tested.
Recent advances in cellular and molecular biology have created the opportunity to isolate pluripotent cells from embryonic tissue, adult bone marrow, and umbilical cord blood.
These results are in agreement with several other clinical studies that reported that MSCs derived from different tissues including bone marrow and umbilical cord have shown therapeutic potentials in clinical studies without significant adverse events[19 21].
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