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Endell J, Samuelsson C, Boxhammer R, Strauss S, Steidl S. Effect of MOR202, a human CD38 antibody, in combination with lenalidomide and bortezomib, on bone lysis and tumor load in a physiologic model of myeloma.
Loss of teeth results in irreversible alveolar bone resorption, and untreated dental disease causes alveolar bone lysis that ultimately leads to loss of teeth.
Fracture of the pubic rami can lead to quite marked focal bone lysis, which can be difficult to differentiate from a destructive malignancy.
Seil R et al. [72] tried to correlate the persistent pain experienced by some patients to the penetration of calcium into bone as a result of the cortical erosion and the biochemical effects of bone lysis.
The treatment inhibits bone lysis and reduced osteoclast activity as expected.
This is certainly true of osteolytic tumours, but the effects of ZOL treatment on tumours that are not dependent upon bone lysis are poorly understood.
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The significant amplification of stem pump provides a potentially important mechanism for facilitatation of aseptic loosening of the stem by forcing fluid and wear debris through cement mantle defects and into direct contact with the underlying bone, causing lysis (McEvoy et al. 2002).
In these cases, intracomponent femoral bone will show lysis and often necrosis.
DNA was extracted from blood and bone marrow after lysis of erythrocytes and from snap frozen tissues after homogenization with FastPrep by Phenol-Chloroform.
Murine-derived plasmacytoid dendritic cells (mu-pDCs) were prepared by Flt3-treatment of mouse bone marrow following RBC lysis.
The main radiological features include osteophytes and increased subchondral bone density (with occasional lysis or cyst-like lesions in the subchondral bone) and end-stage joint space reduction.
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