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Bone turnover markers (BTM) predict bone loss and fragility fracture.
However, aromatase inhibitor therapy increases bone turnover as a result of nearly complete oestrogen depletion, leading to increases in bone loss and fragility fractures that erode patients' functional independence and quality of life.
Translational methodologies are currently applied to spaceflight related dysregulations in the areas of: (1) cardiovascular fluid shifts, intracranial hypertension and neuro-ocular impairment 2) immune insufficiency and suppression/viral re-expression, 3) bone loss and fragility (osteopenia/osteoporosis) and muscle wasting, and finally 4) radiation sensitivity and advanced ageing.
Aging stress generally causes bone loss and fragility [ 38].
Therefore, clinical and laboratory evaluation of aged male osteoporotics must be thorough and should be aimed at identifying lifestyle or conditions contributing to bone loss and fragility.
In patients with systemic lupus erythematosus (SLE), an increase in bone loss and fragility fracture was found compared with general population [ 11].
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In osteoporosis, for example, this disruption leads to long-term bone loss and increased fragility, and can ultimately result in fractures.
Patients with chronic inflammatory diseases have increased bone loss and bone fragility and are at increased risk of fracture.
The authors suggested that high impact jump exercise may provide greater safety margin against disuse-related or/and age-related bone loss and skeletal fragility later in life.
Age- and estrogen deficiency-related failure of the mechanisms involved is associated with bone loss and increase in fragility fractures.
Other studies using involuntary cyclical loading animal models show that fatigue loading of bone leads to bone matrix or cell disruption [ 28, 112], and increased bone resorption leading to a net bone loss and enhanced bone fragility [ 113, 114].
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