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Bisphosphonates derive from the union of two phosphonic acids joined to one carbon atom; particular formulations are able to interfere with osteoclast precursor activation, preventing bone linkage and slowing bone resorption [21].
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The geometry and internal structure of the ossified skeleton determine how external forces are conducted by, through and in-between bones forming linkages and articulation points.
Cyclosporine has for years been believed to affect bone metabolism; a similar linkage between tacrolimus and bone metabolism is suspected but less well documented [ 10].
Receptor activator of nuclear factor kappa B ligand (RANKL) is in the concept of osteoimmunology; a key molecule in the regulation of bone metabolism and the linkage between immune and skeletal systems [ 15, 16].
However, the inbred nature of the mice restricts the mapping resolution that can be obtained, and most established linkages with bone parameters have not resulted in identification of the causative gene.
To date, more than fifteen genome-wide linkage scans for bone mineral density (BMD) have been performed in study populations of different ethnicity, of which two were Chinese.
We also applied the proposed method to a set of real data and detected a coincident linkage responsible for determining bone mineral density and areal bone size of wrist in humans.
Therefore, efforts have focused on the reduction of ligament fibre movement within the bone tunnel and the elimination of linkage materials that may impair healing of the graft-tunnel interface.
In man and in animal models, many loci with effects on bone traits have been identified by linkage- and QTL-analyses (reviewed in [ 12]).
Each bone was represented as a rigid-body linkage with inertial parameters, and the bones were connected to each other via spherical joints.
These results collectively indicate a possible pathophysiological linkage between the distribution of bone-marrow-derived neural progenitors in tissues and systemic SDF-1 levels.
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