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- In vivo, osteoblasts differentiate either to bone lining cells or to osteocytes; about two-thirds undergo apoptosis.
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We were unable to detect GFP expression by endothelial cells, or by Osteopontin+ bone lining cells in the diaphysis or metaphysis.
At this stage, the mature osteoblasts can undergo apoptosis or become osteocytes or bone lining cells [ 47, 48].
Bone lining cells lineup the resting surface.
There was a strong association between radiation-induced marrow cell death and activation of bone lining cells to express the osteoblast phenotype (Pearson correlation − 0.85, p < 0.0001).
Bone lining cells have the capability to form bone, following no former bone resorption, in reaction to bone anabolic agents and may govern mineral homeostasis with the composite of osteoblasts and osteocytes (Kerschnitzki et al. 2013).
In summary, radiation-induced death of marrow cells is associated with 1) a transient increase in bone formation due, at least in part, to activation of bone lining cells, and 2) an increase in bone resorption due to increased osteoclast perimeter.
The endosteal surface of bones is covered not only by a heterogeneous cell population called bone lining cells [11], [24], but also by actively bone-producing osteoblasts [24].
However, osteoblast lineage cells that are found within the subendosteal niche include osteoprogenitor cells, quiescent bone lining cells, and active osteoblasts [11], [24].
Bone lining cells appear microscopically as relatively undifferentiated cells that line the bone.
stimulate progenitor cell recruitment and activate formerly quiescent bone lining cells.
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