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Bone lining cells lineup the resting surface.
Islands of hydroxyapatite particles were observed entrapped in the mineralized bone lining the internal pores of the enriched scaffold.
There was a strong association between radiation-induced marrow cell death and activation of bone lining cells to express the osteoblast phenotype (Pearson correlation − 0.85, p < 0.0001).
Bone lining cells have the capability to form bone, following no former bone resorption, in reaction to bone anabolic agents and may govern mineral homeostasis with the composite of osteoblasts and osteocytes (Kerschnitzki et al. 2013).
The aberrant bone formation correlated with increased numbers of tartrate resistant acid phosphatase positive osteoclasts and decreased numbers of bone lining osteoblasts in 4 week old Osx:EfnB1−/− mice, compared to Osx Cre control mice.
The endosteal surface of bones is covered not only by a heterogeneous cell population called bone lining cells [11], [24], but also by actively bone-producing osteoblasts [24].
However, osteoblast lineage cells that are found within the subendosteal niche include osteoprogenitor cells, quiescent bone lining cells, and active osteoblasts [11], [24].
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Quiescent HSCs reside preferentially at the endosteal region where bone-lining osteoblasts and their secreted proteins are critical components of HSC niches.
The activity of MMPs is regulated by the four members of the Tissue Inhibitor of Metalloproteinases (TIMP) family, which are mainly expressed by chondrocytes and bone-lining cells [42].
Bone-lining cells were arranged along the surface of the bone (Fig. 2a).
Many anchoring fibres extended from the bone toward the interface and passed between the bone-lining cells.
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