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Other studies using involuntary cyclical loading animal models show that fatigue loading of bone leads to bone matrix or cell disruption [ 28, 112], and increased bone resorption leading to a net bone loss and enhanced bone fragility [ 113, 114].
But he was also afflicted with avascular bone necrosis, a condition in which diminished blood supply to the bone leads to serious weakening or destruction of tissue.
During aging, the inflammation and tissue remodelling in chondral tissue around bone leads to calcification and ossification (Hayes et al., 2013).
Diffusion of F-fluoride through capillaries into bone leads to fluoroapatite formation.
For instance, among animal studies, surgical damage to subchondral bone leads to degradation in the overlying cartilage in canines [ 3].
Furthermore, the mechanical mismatch between the Optan stem and the femoral bone leads to stress shielding and subsequent bone resorption in the proximal femur.
Similar(47)
The team found that incremental mechanical loading of up to 30% strain on fractured bone led to a corresponding increase in Cx43 expression.
However, especially in small defects, possible donor-site morbidity, limited graft volume availability and additional length of operation for harvesting autologous bone led to the increasing usage of xenogeneic biomaterials such as demineralized bovine bone substitute (DBBS Bio-Oss©).
The fibroblasts genesis in zones of adaptive remodeling of spongy bones leads to a further development of fibrous tissue that is not subject to mineralization.
Consequently, in the long term, the strain adaptive nature of bones leads to bone resorption, implant loosening, and the need for arthroplasty revision.
Lack of stress on the bones leads to mineral loss and weakening.
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