The mechano-responsiveness of bone was recognized as early as the 16th century [1], and since, it has been presumed that a threshold of 0.1% strain would have to be exceeded to become anabolic [2], while strains below this level of deformation were considered insufficient to retain tissue morphology and thus would be permissive to catabolism [3], [4].
Bone remodeling, which is recognized as the last stage of fracture healing, was found to take place vigorously in mir-21-MSCs treatment group.
Tissue-engineered bone without intrinsic vascular network is recognized as "dead bone".
Owing to its resemblance to the major inorganic constituent of bone and tooth, hydroxyapatite is recognized as one of the most biocompatible materials and is widely used in systems for bone replacement and regeneration.
Osteoporosis is a metabolic bone disease detected mostly in postmenopausal women and is recognized as a major health problem in many countries.
Physical activity is recognized as one of the factors that influence bone mineral density (BMD) and bone quality after total knee arthroplasty (TKA).
Although xanthogranulomatous inflammation is recognized as a subtype of cholecystitis, xanthogranulomatosis of the kidney, bone, ovary, endometrium, vagina, prostate, lymph nodes, and pancreas was reported [1, 2].
3– 5 Interest waned in the 1940s, though it was proposed that the bone marrow be recognized as a site of conventional fat storage.
