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Bone involvement is usually present in patients, and the imaging findings are pathognomonic of ECD.
Bone involvement is bilateral and symmetric with diaphyseal and metaphyseal heterogeneous osteosclerosis.
Bone involvement is accompanied by systemic and regional clinical presentations such as pain, fever, and leukocytosis.
Twenty-five years later, bone involvement is the more specific and characteristic feature of this syndrome.
On the left ischiatic region, a deep infected soft tissue ulcer with bone involvement is shown (large arrow).
Bone involvement is almost universal in ECD (96%% of cases) [4, 5], and more than 50%% of cases have at least one associated extraskeletal involvement [5], namely the kidney, skin, central nervous system or heart.
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Most patients with bone involvement are asymptomatic.
Hence bone involvement was not present in our population.
Furthermore, the IPS of all patients with bone involvement was higher.
*SB-DLBCL with recurrent bone involvement was not included in the table.
Patients with bone involvement were predominantly females (P = 0.026), whereas patients with involvement of other sites were predominantly males.
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