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Both patients where wheelchair-bound at adult age, with very short stature, severe bone involvement and normal intellectual and neurological development [ 10].
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Hindlimbs of the mice were scanned using μCT to assess bone involvement and measure tumor volume.
A significant correlation was observed between the incidence of bone involvement and the serum PSA concentration.
Most of these patients had a favorable PS, no bulky mass, no evidence of B symptoms, no liver, spleen, or bone marrow involvement, and normal liver function.
To this end, we used a public gene expression profile containing data for normal mouse calvarial bone, normal mouse ulnar bone and normal mouse mandibular bone (GSE13563).
Bone involvement is bilateral and symmetric with diaphyseal and metaphyseal heterogeneous osteosclerosis.
A recent study demonstrated a simultaneous visualization of bone and normal bone vasculature in mice.
Metaiodobenzylguanidine (mIBG) scintigraphy is valuable in assessing bone and bone marrow involvement and in following response to therapy.
The most common manifestations of this disease are bone involvement, renal disease and hematologic disorders.
Bone involvement, both silent and symptomatic, was present in almost all patients.
Additionally, the percentage of patients with CNS involvement was 1.3%, with mediastinal involvement in 11.8% and bone involvement in 6.6%.
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