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In this study, we investigated the effect of erlotinib, an orally active EGFR tyrosine kinase inhibitor (TKI), on the bone invasion of human non-small-cell lung cancer (NSCLC) cell line NCI-H292.
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To examine the effects of erlotinib on bone metastasis of NSCLC, we established a novel in vivo intratibial osteolytic bone invasion model of the human NSCLC cell line NCI-H292.
A microfluidics assay to study invasion of human placental trophoblast cells.J R Soc Interface.
Xu, L. et al. MEK4 function, genistein treatment, and invasion of human prostate cancer cells.
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Here, we find that ATG16L1 facilitates bacterial invasion and that the ATG16L1 T300A variant reduces invasion of human cells by Salmonella.
The model proposed in this study is based on human bone invasion by a contiguous human tumor mass; it doesn't replicate the comprehensive metastatic process (evasion from primary tumor, vessel invasion and survival in the blood circulation), rather focuses on cancer cell bone invasion capability.
Strong correlation was found between PTHrP overexpression and local bone invasion and percentage of tumor cells in metastatic nodes.
Wang W, Weng Y, Ren W, Zhang Z, Wang T, Wang J, et al. Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells.
Our mice model of bone invasion by contiguous tumor mass showed similar histology and IL-7 patterns compared to human pathology.
Bone invasion appeared to have the same histological characteristics of human metastasis, such as bone resorption, neo-apposition and tumor nested within the bone tissue.
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