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(2) Do the new surface structures allow good bone ingrowth compared to conventionally made implant surfaces?
This allows a higher rate of bone ingrowth compared to conventional porous coatings, and increased interface shear strength (Bobyn et al. 1999a, b).
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Local treatment at surgery resulted in both denser bone and a reduced bone ingrowth distance compared to systemic treatment.
The cubic structure showed greater bone ingrowth depth compared to the wave structure.
At early time points, Ostim® showed much better microscopic signs of osteointegration, osteoconduction and overall bone ingrowth when compared to the Alpha-BSM®.
In specimens treated with the high dose alendronate, there was no difference in the distance advanced by the bone ingrowth frontier compared to controls (alendronate 2.8 mm. sd 1.1, control 2.5 mm. sd 1.0).
Microporous HA scaffolds revealed four times more bone ingrowth and seven times higher bone contact area compared to the ZrO2 scaffolds.
In a clinical study, micro-porous-coated zirconia scaffolds demonstrated four times higher bone ingrowth and seven times higher bone-scaffold contact compared to uncoated scaffolds inserted in the maxilla of human patient [5].
Porous PEEK substantially increased the load share transferred to ingrown bone compared to porous Ti under compression (i.e. at 4 weeks: PEEK = 66%; Ti = 13%), tension (PEEK = 71%; Ti = 12%), and shear (PEEK = 68%; Ti = 9%) at all time points of simulated bone ingrowth.
This could lead to inferior stability or loss of bone mineral density (BMD) when compared to uncoated cups, where long-lasting bone ingrowth can take place.
These properties appear to explain the significantly increased ingrowth of bone of the Ostim® group compared to the Alpha-BSM® group.
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