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It should also be able to maintain space for new bone infiltration and readily available in clinics.
Compared to bone infiltration and pore arrangement and orientation, relative pore size and shape have relatively small effect on the mechanical responses.
Bone infiltration greatly reduces the stress concentration in such regions indicating an advantage of bone ingrowth beyond improved interface and attachment.
Five microstructural features are varied to create 32 test cases to study the effects of pore shape, size, orientation, and arrangement, and bone infiltration.
The results of the DOE studies of both 2D and 3D numerical simulations demonstrate that bone infiltration into the pores is the most dominant factor for elastic modulus and yield stress.
In the present study, finite element modeling (FEM) was used to re-design the scaffold microstructure to improve its flexural strength without significantly lowering its compressive strength and ability to support bone infiltration in vivo.
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Tumor features such as sinus or bone infiltrations were routinely detected on preoperative MR and CT images.
MRI and PET analysis alone were each able to detect these bone infiltrations but were also associated with one false positive diagnosis each in other cases.
And in patients with stage 3 disease according to Salmon and Durie, a diffuse bone marrow infiltration, as shown on MR images, was associated with a worse prognosis than a multifocal bone marrow infiltration [ 10, 11].
No bone marrow infiltration by abnormal cells was observed.
Open image in new window Fig. 9 Bone marrow infiltration patterns.
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