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Further, osteocalcin has been observed to be high in cortical bone in comparison to trabecular bone [35, 36].
Both types of cells, MSC and EPC, demonstrated a significantly decreased adherence on bovine cancellous bone in comparison to β-TCP and processed mineralized human cancellous chips [ 23, 24].
The new fixation method invented by Rogala [ 23– 25] and the MSC-Scaffold preprototype designed in our research team [ 27, 28] assumes more physiological load transmission in peri-implant bone in comparison to the traditional short-stem cemented RHA endoprostheses.
Epiphyseal bone healing improved in all the osteochondral defects regardless of treatment, although PEMFs alone did not significantly improve the reconstruction of subchondral bone in comparison to treatment with scaffold alone.
This could have been due to very strong expression of sclerostin in the unloaded bone, in comparison to normally-loaded bone, in which case the amount of antibody administered may have been inadequate to fully inhibit sclerostin.
A marked lower initial adherence was observed on bovine cancellous bone in comparison to β-TCP and DBM, whereas adhesion on β-TCP and DBM was at a comparable, high level).
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Apart from the inhibition of mineralization by the pASARM peptide, there were no other obvious morphological differences in the development of these bones in comparison to the control bones.
The significant higher levels of Sr and Ca in bones in comparison to that in soil was considered as an indication that Sr and Ca levels represent the biological levels, but the main argument against diagenesis was the results showed by the significant correlation between the Sr/Ca ratio and the Ba/Ca ratio that indicate that these ratios reflect the biological values.
In addition, we found a significantly higher polyethylene wear rate in type III femoral bone loss in comparison to bone defects of type I and II (Mann-Whitney U test; p = 0.007 and p = 0.015 for linear and volumetric wear rate, respectively).
We also observed significantly increased plasma OPN levels among myeloma patients with overt bone disease in comparison to those who had normal bone radiologic findings.
Schepers and Ducheyne [ 60] evaluated bone growth around bioactive glass particles in dog bone defects in comparison to hydroxylapatite particles, and reported that narrow-size (300– 355 mm) BG has an osteostimulatory effect besides its osteoconductive properties.
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