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In vivo, the scaffolds were found to regenerate bone in a rabbit model according to X-ray micro tomography imaging.
This study showed a significant association between vBMD and the modulus of elasticity, yield stress and failure stress of regenerate bone in a rabbit DO model.
Using demineralized, freeze-dried bone in a rabbit model, Urist et al. reported that particles 250 to 420 μm in size interrupted chondrogenesis and ossification, whereas those 1000 to 2000 μm in size were more effective [26].
Whether a prolonged GC treatment was needed to keep osteopenic bone in a rabbit model of osteoporosis was not decided in our study.
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These results confirm a previous paper of Giavaresi et al., who demonstrated that soybean-based hydrogels promote bone formation in a rabbit bone defect model [12].
Then, as a result of his 1965 experiment in which demineralized, pulverized bone implanted in a rabbit's muscle caused bone to form at the site, he theorized that some kind of protein in bone must be responsible for such growth.
This study used synchrotron X-ray microtomography on a micron scale to compare three-dimensional (3D) bone ingrowth after implantation of various calcium phosphate bone substitutes in a rabbit model.
Chitosan/PLAGA-based scaffolds were able to guide bone formation in a rabbit ulnar critical-sized-defect model.
Furthermore, the surfaces with the highest osteogenic potential in vitro also demonstrated their osteogenic effect in vivo: these indeed strongly enhanced bone bonding in a rabbit femur model.
Furthermore, an in vivo result showed that GDF-5 loaded Ti had a significant influence on new bone formation in a rabbit model.
The present study has been designed in vivo to evaluate the effects of osteogenic medium on healing of experimental critical bone defect in a rabbit model.
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