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In this study, we report the vascularity and the metabolic bone function in the proximal femur in these same patients at one year after the surgery.
For these reasons, and the strong evidence of substantial reliability in definitions of ROIs (ICCs of 0.694 and 0.666 for ROI 1 and ROI 2, respectively), we believe that the results do provide evidence for differences in metabolic bone function in the inter-trochanteric region (ROI 2) and no significant difference at the head/neck junction (ROI 1) despite the small number of patients.
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Here we characterize alterations in the biomechanical responses of bones from PPARβ−/− mice and identify new molecular targets, namely PPARγ and myostatin, that may contribute to the impairment of the muscle and bone functions in diabetes.
Vitamin A is well known to be important for animal growth, development and various physiological processes, such as keeping the normal sight and bone function, especially in neonatal and growing animals [ 1].
These abnormalities in bone function are reflected in abnormal levels of serum and urinary collagen breakdown products, which may therefore be exploited as biochemical markers to monitor progress of the disease and the effectiveness of bisphosphonate therapy.
You et al. [ 102] reported that the zinc finger protein Zfp467 stimulated osteoblast differentiation of cultured adipose-derived stem cells, and that Zfp467-targeted RNAi could restore bone function and structure in an ovariectomy-induced osteoporotic mouse model.
Disruption of this balance leads to osteoporosis characterized by decline in bone function and skeletal rigidity.
This suggests that scaling is highly sensitive to regional variation in bone function.
Examining whole bones revealed that bone allometry is strongly affected by regional variations in bone function, presumably through mechanical effects on bone modelling.
The goal of this work was to extend a mathematical, multiscale systems model of bone function, remodeling, and health in order to explore hypotheses related to therapeutic modulation of sclerostin and quantitatively describe purported osteocyte activity within bone remodeling events.
Group 1: "functional limb" (limbs reconstructed to restore a muscular or bone function); eight patients were listed in this group (Table 3).
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